{"product_id":"reed-biotech-ps-1-polyclonal-antibody-ra29044","title":"PS-1 Polyclonal Antibody","description":"\u003cp\u003epresenilin 1(PSEN1) Homo sapiens Alzheimer\u0026amp;apos;s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250990457172,"sku":"ABM5033438-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250990489940,"sku":"ABM5033438-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_5898929d-2df3-4ed7-83f1-5140f94f86fd.webp?v=1790234967","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-ps-1-polyclonal-antibody-ra29044","provider":"ABMIUM","version":"1.0","type":"link"}