{"product_id":"reed-biotech-pebp2beta-polyclonal-antibody-ra28664","title":"PEBP2β Polyclonal Antibody","description":"\u003cp\u003ecore-binding factor beta subunit(CBFB) Homo sapiens The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2\/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11.\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250429141332,"sku":"ABM5033058-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250429174100,"sku":"ABM5033058-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_19328c6b-c4d6-44a7-85ac-1b3ce2b8f062.webp?v=1790234862","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-pebp2beta-polyclonal-antibody-ra28664","provider":"ABMIUM","version":"1.0","type":"link"}