{"product_id":"reed-biotech-pdha1-2-rabbit-polyclonal-antibody-ra36705","title":"PDHA1\/2 Rabbit Polyclonal Antibody","description":"\u003cp\u003epyruvate dehydrogenase (lipoamide) alpha 1(PDHA1) Homo sapiens The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57249642938708,"sku":"ABM5041099-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57249642971476,"sku":"ABM5041099-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_3a95c8d7-c720-44a7-987f-635aa300e86b.webp?v=1790234855","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-pdha1-2-rabbit-polyclonal-antibody-ra36705","provider":"ABMIUM","version":"1.0","type":"link"}