{"product_id":"reed-biotech-paf-r-polyclonal-antibody-ra28470","title":"PAF-R Polyclonal Antibody","description":"\u003cp\u003eplatelet activating factor receptor(PTAFR) Homo sapiens This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and\/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250954740052,"sku":"ABM5032864-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250954772820,"sku":"ABM5032864-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_c6df9122-68ec-4f91-92a5-b5a9b50f48f3.webp?v=1790234813","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-paf-r-polyclonal-antibody-ra28470","provider":"ABMIUM","version":"1.0","type":"link"}