{"product_id":"reed-biotech-p40-phox-polyclonal-antibody-ra20584","title":"p40-phox Polyclonal Antibody","description":"\u003cp\u003eneutrophil cytosolic factor 4(NCF4) Homo sapiens The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2\/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1\/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57248235782484,"sku":"ABM5024978-1","price":137.0,"currency_code":"USD","in_stock":true},{"title":"100 µL","offer_id":57248235815252,"sku":"ABM5024978-2","price":184.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_e5478d55-5435-459f-965b-b01574c1fde0.webp?v=1790234790","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-p40-phox-polyclonal-antibody-ra20584","provider":"ABMIUM","version":"1.0","type":"link"}