{"product_id":"reed-biotech-nse2-polyclonal-antibody-ra33645","title":"NSE2 Polyclonal Antibody","description":"\u003cp\u003efunction:E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,similarity:Belongs to the NSE2 family.,similarity:Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2\/MMS21 and probably NSMCE1.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250277654868,"sku":"ABM5038039-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250277687636,"sku":"ABM5038039-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_dfbb7603-8cc7-4ea4-8af5-387da215c825.webp?v=1790234663","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-nse2-polyclonal-antibody-ra33645","provider":"ABMIUM","version":"1.0","type":"link"}