{"product_id":"reed-biotech-er81-monoclonal-antibody-ra11166","title":"ER81 Monoclonal Antibody","description":"\u003cp\u003eETS variant 1(ETV1) Homo sapiens This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5\u0026amp;apos;-CGGA[AT]-3\u0026amp;apos;. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alte\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57249910686036,"sku":"ABM5041996-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57249910718804,"sku":"ABM5041996-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/es\/products\/reed-biotech-er81-monoclonal-antibody-ra11166","provider":"ABMIUM","version":"1.0","type":"link"}