{"product_id":"rabbit-polyclonal-antibody-to-spin1-p07621","title":"Anti-SPIN1 Rabbit Polyclonal Antibody","description":"\u003cp\u003eChromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis. SPIN1 plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58006734537044,"sku":"ABM403371-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58006734569812,"sku":"ABM403371-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58006734602580,"sku":"ABM403371-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/es\/products\/rabbit-polyclonal-antibody-to-spin1-p07621","provider":"ABMIUM","version":"1.0","type":"link"}