{"product_id":"rabbit-polyclonal-antibody-to-pkr-phospho-thr446-p41235","title":"Anti-PKR (Phospho-Thr446) Rabbit Polyclonal Antibody","description":"\u003cp\u003eIFN-induced dsRNA-dependent serine\/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1\/eIF-2-alpha) and plays a key role in the innate immune response to viral infection. EIF2AK2 inhibits viral replication via the integrated stress response (ISR): EIF2S1\/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1\/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58162321326420,"sku":"ABM418535-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58162321359188,"sku":"ABM418535-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58162321391956,"sku":"ABM418535-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/es\/products\/rabbit-polyclonal-antibody-to-pkr-phospho-thr446-p41235","provider":"ABMIUM","version":"1.0","type":"link"}