{"product_id":"rabbit-polyclonal-antibody-to-ints11-p09649","title":"Anti-INTS11 Rabbit Polyclonal Antibody","description":"\u003cp\u003eRNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A\/RPB1 and SUPT5H\/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58006963814740,"sku":"ABM404966-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58006963847508,"sku":"ABM404966-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58006963880276,"sku":"ABM404966-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/es\/products\/rabbit-polyclonal-antibody-to-ints11-p09649","provider":"ABMIUM","version":"1.0","type":"link"}