{"product_id":"rabbit-polyclonal-antibody-to-dectin-2-p23287","title":"Anti-Dectin-2 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eCLEC6A\u003c\/strong\u003e is a calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. CLEC6A recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58024837710164,"sku":"ABM413010-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58024837742932,"sku":"ABM413010-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58024837775700,"sku":"ABM413010-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/es\/products\/rabbit-polyclonal-antibody-to-dectin-2-p23287","provider":"ABMIUM","version":"1.0","type":"link"}