{"product_id":"proteogenix-human-flt1-recombinant-protein","title":"Human FLT1 recombinant protein","description":"\u003ch2\u003eGeneral information on Human FLT1 recombinant protein\u003c\/h2\u003e Human FLT1 Recombinant Protein: Structure and Activity \u003cp\u003eHuman Fms-like tyrosine kinase 1 (FLT1) is a type I membrane receptor belonging to the vascular endothelial growth factor receptor (VEGFR) family. It is composed of an extracellular domain, a single transmembrane domain, and an intracellular domain. The extracellular domain of FLT1 binds to VEGF-A, VEGF-C, and VEGF-D, while the intracellular domain has tyrosine kinase activity. FLT1 is involved in the regulation of angiogenesis, vascular permeability, and cell proliferation.\u003c\/p\u003e FLT1 as an Antibody-Drug Target \u003cp\u003eFLT1 is an attractive target for antibody-drug conjugates (ADCs) due to its role in tumor growth and angiogenesis. ADCs are composed of an antibody linked to a cytotoxic drug. The antibody binds to the FLT1 receptor and the drug is internalized, leading to cell death. FLT1-targeted ADCs have been used in clinical trials for various types of cancer, including ovarian, gastric, and colorectal cancers.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number PX-P6096. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Mammalian cells; Expression system: Eukaryotic expression; Purity: \u0026gt;85% by SDS-PAGE; Molecular weight: 37.77 kDa; Tag: C-Terminal His Tag; Fragment: Met1-Ile328; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA, WB.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/PX-P6096.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"100ug","offer_id":57359168274772,"sku":"ABM144357-1","price":279.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/bioactivity-validation-human-flt1-recombinant-protein_01a17d1e-9452-4a14-872b-7b0ba067d4bc.jpg?v=1790895021","url":"https:\/\/www.abmium.com\/es\/products\/proteogenix-human-flt1-recombinant-protein","provider":"ABMIUM","version":"1.0","type":"link"}