{"product_id":"proteogenix-cd80-recombinant-protein","title":"CD80 Recombinant Protein","description":"\u003ch2\u003eGeneral information on CD80 Recombinant Protein:\u003c\/h2\u003e \u003cp\u003eCluster of Differentiation 80, also known as B7-1, is a member of the cell surface immunoglobulin superfamily. It is expressed on the surface of antigen presenting cells, including activated B cells, macrophages and dendritic cells. CD80 plays a fundamental but different role in the activation of T cells. B7-1 \/ CD80 and B7-2 \/ CD86 and its CD28 and CTLA4 receptors constitute one of the main co-stimulatory pathways that regulate the response of T and B cells. CD80 is mainly expressed on the surface of antigen presenting cells, including activated B cells, macrophages and dendritic cells. Although CTLA-4 and CD28 can bind to the same ligand, CTLA-4 binds B7-1 and B7-2 with an affinity 20-100 times greater than CD28 and participates in the negative regulation of immune responses. Therefore, CD80 is considered a promising therapeutic target for autoimmune diseases and various types of cancer.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number PX-P4090. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Mammalian cells; Expression system: Eukaryotic expression; Purity: \u0026gt;90% by SDS-PAGE; Molecular weight: 45kDa; Tag: C-terminal His Tag; Fragment: Met1~Asn242; Buffer: PBS pH7.5; Applications: ELISA, WB.\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/PX-P4090.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57376163365204,"sku":"ABM146366-1","price":103.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57376163397972,"sku":"ABM146366-2","price":175.2,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57376163430740,"sku":"ABM146366-3","price":508.0,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/es\/products\/proteogenix-cd80-recombinant-protein","provider":"ABMIUM","version":"1.0","type":"link"}