{"product_id":"human-klotho-beta-klb-elisa-kit-picokine-ek1492","title":"Human Klotho beta\/KLB ELISA Kit PicoKine®","description":"\u003cp\u003eHuman Klotho beta\/KLB ELISA Kit PicoKine® is a research-use ELISA kit from Boster Bio for measuring Beta-klotho in Cell culture supernatant, Cell lysates, serum and plasma (heparin, EDTA). samples from Human. Use the listed assay range, sample guidance and protocol documents to assess suitability for the intended study.\u003c\/p\u003e\nHuman Klotho beta ELISA Kit PicoKine® (96 Tests). Quantitate Human KLB in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 50pg\/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.\u003cp\u003eKlotho beta, a divergent structural member of the glycosidase I superfamily, is expressed primarily in the liver and pancreas, with lower expression in adipose tissue. It is mapped to chromosome 4. The Klotho beta mediated interaction of human FGF19 (mouse FGF15) with FGF Receptor 4 in the liver negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes, cholesterol 7-alpha hydroxylase (Cyp7a1) and sterol 12-alpha hydroxylase (Cyp8b1). Klotho beta is also an essential cofactor for FGF21 activity and the Klotho gene family may have evolved to confer tissue-specific bioactivity on FGF19 subfamily members.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":56042478010708,"sku":"ABM33262","price":678.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ek1492_1.png?v=1781656690","url":"https:\/\/www.abmium.com\/es\/products\/human-klotho-beta-klb-elisa-kit-picokine-ek1492","provider":"ABMIUM","version":"1.0","type":"link"}