{"product_id":"anti-orai1-antibody-picoband-a00909","title":"Anti-Orai1 Antibody Picoband®","description":"\u003cp\u003eAnti-Orai1 Antibody Picoband® is a research-use antibody from Boster Bio for studying Calcium release-activated calcium channel protein 1 in ELISA, Flow Cytometry, IHC, IHC-P, WB workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.\u003c\/p\u003e\nBoster Bio Anti-Orai1 Antibody catalog # A00909. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.\u003cp\u003eORAI1 (ORAI calcium release-activated calcium modulator 1), also known as CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, FLJ14466, is a calcium selectiveion channelthat in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans. The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers.Prakriya et al. showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments. Glu106-to-asp (E106D) and glu190-to-gln (E190Q) substitutions in transmembrane helices 1 and 3, respectively, diminished calcium ion influx, increased current carried by monovalent cations, and rendered the channel permeable to cesium ion.Prakriya et al. showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e","brand":"Boster Bio","offers":[{"title":"Unconjugated \/ 100 μg\/vial","offer_id":56040253325652,"sku":"ABM22724-1","price":328.0,"currency_code":"GBP","in_stock":true},{"title":"Biotin \/ 100 μg\/vial","offer_id":56040253358420,"sku":"ABM22724-2","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"Cy3 \/ 100 μg\/vial","offer_id":56040253391188,"sku":"ABM22724-3","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"Fluoro488 \/ 100 μg\/vial","offer_id":56040253423956,"sku":"ABM22724-4","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"Fluoro550 \/ 100 μg\/vial","offer_id":56040253456724,"sku":"ABM22724-5","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"Fluoro594 \/ 100 μg\/vial","offer_id":56040253489492,"sku":"ABM22724-6","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"FITC \/ 100 μg\/vial","offer_id":56040253522260,"sku":"ABM22724-7","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"HRP \/ 100 μg\/vial","offer_id":56040253555028,"sku":"ABM22724-8","price":505.0,"currency_code":"GBP","in_stock":true},{"title":"APC \/ 100 μg\/vial","offer_id":56040253587796,"sku":"ABM22724-9","price":726.0,"currency_code":"GBP","in_stock":true},{"title":"PE \/ 100 μg\/vial","offer_id":56040253620564,"sku":"ABM22724-10","price":726.0,"currency_code":"GBP","in_stock":true},{"title":"Fluoro647 \/ 100 μg\/vial","offer_id":56040253653332,"sku":"ABM22724-11","price":593.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/a00909-orai1-primary-antibodies-wb-testing-1.jpg?v=1781645837","url":"https:\/\/www.abmium.com\/es\/products\/anti-orai1-antibody-picoband-a00909","provider":"ABMIUM","version":"1.0","type":"link"}