{"product_id":"abm216766","title":"Human Interleukin Enhancer-binding Factor 3, ILF3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eRNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed: 28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed: 14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed: 21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase\/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed: 21123651, PubMed: 28625552).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662012260692,"sku":"ABM216766","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662012293460,"sku":"ABM216767","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-bd68733dcfe276cc71f6f4a08b65f2be52f84ad84fc4c8351abcc1b31e26d024.jpg?v=1792159241","url":"https:\/\/www.abmium.com\/es\/products\/abm216766","provider":"ABMIUM","version":"1.0","type":"link"}