{"product_id":"abm216652","title":"Human Homeobox Protein Nanog, NANOG ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTranscription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1\/OCT4 promoter (PubMed: 25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281\/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661922935124,"sku":"ABM216652","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661922967892,"sku":"ABM216653","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-585901cd3d6854b89d6f581022a709170e6243b6e716b5f29e1d07a7e68208cc.jpg?v=1792159232","url":"https:\/\/www.abmium.com\/es\/products\/abm216652","provider":"ABMIUM","version":"1.0","type":"link"}