{"product_id":"abm216474","title":"Human Gamma-secretase Subunit Aph-1A, APH1A ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eNon-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 12297508, PubMed: 12522139, PubMed: 12763021, PubMed: 12679784, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874). Required for normal gamma-secretase assembly (PubMed: 12522139, PubMed: 12471034, PubMed: 12763021, PubMed: 19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661778755924,"sku":"ABM216474","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661778788692,"sku":"ABM216475","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-694a6114b478ccb01497dc6278b63d60671f8f946400f5c0d1b2b1b09590a825.jpg?v=1792159219","url":"https:\/\/www.abmium.com\/es\/products\/abm216474","provider":"ABMIUM","version":"1.0","type":"link"}