{"product_id":"abm215992","title":"Human Caspase-6, CASP6 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed: 8663580, PubMed: 32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A\/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed: 17401638, PubMed: 8663580, PubMed: 9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein\/CREBBP (PubMed: 10559921, PubMed: 14657026). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed: 32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed: 32298652).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661903143252,"sku":"ABM215992","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661903176020,"sku":"ABM215993","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a2fd18c6960dfa49d12055f6523e3c38ffa3f0a9278c1c0de8a22a749b0c454c.jpg?v=1792159233","url":"https:\/\/www.abmium.com\/es\/products\/abm215992","provider":"ABMIUM","version":"1.0","type":"link"}