{"product_id":"abm215488","title":"Human Fumarate Hydratase, Mitochondrial, FH ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCatalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed: 30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed: 20231875, PubMed: 26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed: 26237645).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662010458452,"sku":"ABM215488","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662010491220,"sku":"ABM215489","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-b7ecea3b93443dffe8c8e433dccd4d60d59dafa3f204290a62213aacdecf88a4.jpg?v=1792159254","url":"https:\/\/www.abmium.com\/es\/products\/abm215488","provider":"ABMIUM","version":"1.0","type":"link"}