{"product_id":"abm214990","title":"Human Nicotinamide Phosphoribosyltransferase, NAMPT ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCatalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL\/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661614063956,"sku":"ABM214990","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661614096724,"sku":"ABM214991","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-74c85905a79ce3877a6b13ddafb80c12c8a37cc76dfdfd6c46c7d473e38a42ef.jpg?v=1792159217","url":"https:\/\/www.abmium.com\/es\/products\/abm214990","provider":"ABMIUM","version":"1.0","type":"link"}