{"product_id":"abm214692","title":"Human Interferon Regulatory Factor 5, IRF5 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTranscription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661880041812,"sku":"ABM214692","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661880074580,"sku":"ABM214693","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1250db301201827c4626223f4f5d91a9c671414fffabbec6f1f2ab46bc08690d.jpg?v=1792159245","url":"https:\/\/www.abmium.com\/es\/products\/abm214692","provider":"ABMIUM","version":"1.0","type":"link"}