{"product_id":"abm211304","title":"Rat Cysteine and Glycine-rich Protein 3, CSRP3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePositive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (PubMed: 7954791, PubMed: 9234731). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC\/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC\/PRKCA signaling (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661802479956,"sku":"ABM211304","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661802512724,"sku":"ABM211305","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a6625215b99bc2691eba899cb6c41f58fc080b015cae609d8bd3712353cb6d19.jpg?v=1792159244","url":"https:\/\/www.abmium.com\/es\/products\/abm211304","provider":"ABMIUM","version":"1.0","type":"link"}