{"product_id":"abm211242","title":"Mouse C-C Chemokine Receptor Type 2, CCR2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eKey functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines (PubMed: 8631787, PubMed: 8662823, PubMed: 8996246). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A\/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (PubMed: 28507030). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (PubMed: 29930553). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed: 29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK\/ERK-dependent phosphorylation of GRIN2B\/NMDAR2B (PubMed: 29993042). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (PubMed: 24806994, PubMed: 29632244).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661738254676,"sku":"ABM211242","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661738287444,"sku":"ABM211243","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-b32a27a07633f8f788acaeeccdfdd363eb030f1bb889ff6d89aa5f0fdbfcb3f9.jpg?v=1792159240","url":"https:\/\/www.abmium.com\/es\/products\/abm211242","provider":"ABMIUM","version":"1.0","type":"link"}