{"product_id":"abm208586","title":"Human Toll-like Receptor 8, TLR8 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eEndosomal receptor that plays a key role in innate and adaptive immunity (PubMed: 25297876, PubMed: 32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed: 31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed: 23520111, PubMed: 25599397, PubMed: 26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed: 16737960, PubMed: 17932028, PubMed: 29155428).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"96T","offer_id":57661638115668,"sku":"ABM208586","price":293.0,"currency_code":"GBP","in_stock":true},{"title":"48T","offer_id":57661638148436,"sku":"ABM208587","price":205.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1be0d5c621da97c4f241ca4c099d2c4bbcc29bad4509a23d5e47ae4038396b64.jpg?v=1792159165","url":"https:\/\/www.abmium.com\/es\/products\/abm208586","provider":"ABMIUM","version":"1.0","type":"link"}