{"product_id":"abm207618","title":"Sheep Insulin-like Growth Factors 1, IGF-1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT\/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3\/ERK1, MAPK1\/ERK2 and AKT1 (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661261971796,"sku":"ABM207618","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661262004564,"sku":"ABM207619","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-81a406c8991e49c23b2f4b2ea69cfaaec622dcd6e3408512a23c6373776e8f1a.jpg?v=1792159095","url":"https:\/\/www.abmium.com\/es\/products\/abm207618","provider":"ABMIUM","version":"1.0","type":"link"}