{"product_id":"abm205367","title":"CD148 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57660823470420,"sku":"ABM205367","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57660823503188,"sku":"ABM205368","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-004c5ee4a38db43bdcccf6cc5b3449018b94a8bf5d1bf357237b10c77fb40506.jpg?v=1792159116","url":"https:\/\/www.abmium.com\/es\/products\/abm205367","provider":"ABMIUM","version":"1.0","type":"link"}