{"product_id":"abm201427","title":"BRAF Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eBRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1; RAFB1; B-RAF1; FLJ95109. Entrez Protein NP_004324. It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439). B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers. The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi, primary cutaneous melanomas and colorectal cancers.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57660953985364,"sku":"ABM201427","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57660954018132,"sku":"ABM201428","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-9ae1d18fee3a72fb196bf49501cb55cd63ba07fd39e4c7a9bcb26fe9f7ddd092.jpg?v=1792158968","url":"https:\/\/www.abmium.com\/es\/products\/abm201427","provider":"ABMIUM","version":"1.0","type":"link"}