{"product_id":"abm200979","title":"GATA3 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eGATA3: GATA binding protein 3. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1,but no other structural homologies between the 2 genes could be found.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661266886996,"sku":"ABM200979","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661266919764,"sku":"ABM200980","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-d2a38a571085bfaba812231fe599837ecc52bb0ce2d10efafdcf9e52e9100f6d.jpg?v=1792159031","url":"https:\/\/www.abmium.com\/es\/products\/abm200979","provider":"ABMIUM","version":"1.0","type":"link"}