{"product_id":"abm200899","title":"IKZF1 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661173334356,"sku":"ABM200899","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661173367124,"sku":"ABM200900","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-273eb16d65a34b4f03801bfe95f4d4683daa4974e67359b480c683ea60f945b5.jpg?v=1792159002","url":"https:\/\/www.abmium.com\/es\/products\/abm200899","provider":"ABMIUM","version":"1.0","type":"link"}