{"product_id":"abm197483","title":"VHL Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660775760212,"sku":"ABM197483","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660775792980,"sku":"ABM197484","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660775825748,"sku":"ABM197485","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1f89ee04be62869ce0b68600ca76724fec450947d3cdf1bb1566f5cb67a896b0.jpg?v=1792158975","url":"https:\/\/www.abmium.com\/es\/products\/abm197483","provider":"ABMIUM","version":"1.0","type":"link"}