{"product_id":"abm197066","title":"DTL Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003edevelopmental stage:Expressed in all fetal tissues examined, included brain, lung, liver, and kidney.,Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the WD repeat cdt2 family.,Contains 7 WD repeats.,subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.,subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1.,tissue specificity:Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661240344916,"sku":"ABM197066","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661240377684,"sku":"ABM197067","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661240410452,"sku":"ABM197068","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/es\/products\/abm197066","provider":"ABMIUM","version":"1.0","type":"link"}