{"product_id":"abm190751","title":"PLB(Phospho Ser16\/T17) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661116449108,"sku":"ABM190751","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661116481876,"sku":"ABM190752","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661116514644,"sku":"ABM190753","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-4a0dba6bd059d5c993d0137d57a86ca520d9a4f16e4a133b4ed255e75ebdd84b.jpg?v=1792158953","url":"https:\/\/www.abmium.com\/es\/products\/abm190751","provider":"ABMIUM","version":"1.0","type":"link"}