{"product_id":"abm187457","title":"NSE2 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eE3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,Belongs to the NSE2 family.,Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2\/MMS21 and probably NSMCE1.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661132112212,"sku":"ABM187457","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661132144980,"sku":"ABM187458","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661132177748,"sku":"ABM187459","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-72dfc3ef8441ab9656273fb175fe81e763157371e4ea5ab95ee9807b43c6c506.jpg?v=1792159000","url":"https:\/\/www.abmium.com\/es\/products\/abm187457","provider":"ABMIUM","version":"1.0","type":"link"}