{"product_id":"abm186446","title":"p21 (Acetyl Lys161\/K163) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eMay be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity| preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.|induction:By p53| mezerein (antileukemic compound) and interferon beta.|PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.|Belongs to the CDI family.|tissue specificity:Expressed in all adult human tissues| with 5-fold lower levels observed in the brain.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661512384852,"sku":"ABM186446","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661512417620,"sku":"ABM186447","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661512450388,"sku":"ABM186448","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/es\/products\/abm186446","provider":"ABMIUM","version":"1.0","type":"link"}