{"product_id":"abm184624","title":"MAML2 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661009887572,"sku":"ABM184624","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661009920340,"sku":"ABM184625","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661009953108,"sku":"ABM184626","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/es\/products\/abm184624","provider":"ABMIUM","version":"1.0","type":"link"}