{"product_id":"abm182389","title":"IL-4R alpha(Phospho Tyr497) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661108650324,"sku":"ABM182389","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661108683092,"sku":"ABM182390","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661108715860,"sku":"ABM182391","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a279d2e849271c9e9b37953da03863f16d7778f036ec191294e693393552cbf9.jpg?v=1792158982","url":"https:\/\/www.abmium.com\/es\/products\/abm182389","provider":"ABMIUM","version":"1.0","type":"link"}