{"product_id":"abm179608","title":"UHRF1 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eUHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. E3 ubiquitin-protein ligase UHRF1binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1\/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659870642516,"sku":"ABM179608","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659870675284,"sku":"ABM179609","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659870708052,"sku":"ABM179610","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-f4b35270f8302614863902b89993396e81c3694d9e1da0c1252ebbc9812be06a.jpg?v=1792158882","url":"https:\/\/www.abmium.com\/es\/products\/abm179608","provider":"ABMIUM","version":"1.0","type":"link"}