{"product_id":"abm174550","title":"RB3 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eRB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10\/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and\/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660643148116,"sku":"ABM174550","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660643180884,"sku":"ABM174551","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660643213652,"sku":"ABM174552","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-d488a27a474b033113851308decc3213e723db14c67b2a97db3380a0f002fdde.jpg?v=1792158810","url":"https:\/\/www.abmium.com\/es\/products\/abm174550","provider":"ABMIUM","version":"1.0","type":"link"}