{"product_id":"abm167788","title":"UBP18 Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus| and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions| and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues| indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon| suggesting a function of this protein in downregulating interferon responses| independent of its isopeptidase activity towards ISG15.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660047393108,"sku":"ABM167788","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660047425876,"sku":"ABM167789","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660047458644,"sku":"ABM167790","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-8d8c5119446819fd3b8a6beca88d1f5e9eb8564c557d3c4630a31ae077ac6de8.jpg?v=1792158872","url":"https:\/\/www.abmium.com\/es\/products\/abm167788","provider":"ABMIUM","version":"1.0","type":"link"}