{"product_id":"abm158200","title":"DCLK1 Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains| which bind microtubules and regulate microtubule polymerization| a C-terminal serine\/threonine protein kinase domain| which shows substantial homology to Ca2+\/calmodulin-dependent protein kinase| and a serine\/proline-rich domain in between the doublecortin and the protein kinase domains| which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes| including neuronal migration| retrograde transport| neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported| but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms| which are differentially expressed and have different kinase activities.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660032942420,"sku":"ABM158200","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660032975188,"sku":"ABM158201","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660033007956,"sku":"ABM158202","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a6e3adcf25a3875f5b7c580711d5c807aa1ccda6736eb0fd6026cda22c3cc5a0.jpg?v=1792157356","url":"https:\/\/www.abmium.com\/es\/products\/abm158200","provider":"ABMIUM","version":"1.0","type":"link"}