{"product_id":"abm157873","title":"Cortactin(Phospho Tyr466) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57659771781460,"sku":"ABM157873","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659771814228,"sku":"ABM157874","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57659771846996,"sku":"ABM157875","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-972ebd3c00d02ad2ced89ab1ae7a929c4fa57512122c0460113ff78199d0fac0.jpg?v=1792157318","url":"https:\/\/www.abmium.com\/es\/products\/abm157873","provider":"ABMIUM","version":"1.0","type":"link"}