{"product_id":"tribio-urmc-099-mlk3-inhibitor","title":"URMC-099, MLK3 inhibitor","description":"\u003cp\u003eURMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM). URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders and facilitated microglial amyloid-β degradation and clearance in mouse models. URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411083239764,"sku":"ABM148915-1","price":311.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411083272532,"sku":"ABM148915-2","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4012.png?v=1791105166","url":"https:\/\/www.abmium.com\/de\/products\/tribio-urmc-099-mlk3-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}