{"product_id":"tribio-unc1999-methyltransferase-inhibitor","title":"UNC1999, Methyltransferase inhibitor","description":"\u003cp\u003eUNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50’s = 45 nM and 2 nM respectively). Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells. It suppresses global H3K27 trimethylation\/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411081503060,"sku":"ABM148911-1","price":327.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411081535828,"sku":"ABM148911-2","price":96.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4542.png?v=1791105162","url":"https:\/\/www.abmium.com\/de\/products\/tribio-unc1999-methyltransferase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}