{"product_id":"tribio-trametinib-mek-inhibitor","title":"Trametinib, MEK inhibitor","description":"\u003cp\u003eTrametinib is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM) and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM; IC50 HT-29 = 0.57 nM). It is approved for use against unresectable or metastatic BRAF-mutant melanoma alone or in combination with Dabrafenib. Trametinib can limit outgrowth of tumors without directly inhibiting tumor cell proliferation via abrogation of cytokine-driven expansion of monocytic myeloid-derived suppressor cells (mMDSC) through a mechanism involving CD8+ T cells. Trametinib also displays potent anti-arthritic effects\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57411085304148,"sku":"ABM148875-1","price":65.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57411085336916,"sku":"ABM148875-2","price":245.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4759.png?v=1791105170","url":"https:\/\/www.abmium.com\/de\/products\/tribio-trametinib-mek-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}