{"product_id":"tribio-thz1-cdk7-inhibitor","title":"THZ1, CDK7 inhibitor","description":"\u003cp\u003eTHZ1 is an irreversible, covalent inhibitor (dual ATP-site and allosteric covalent binding) of CDK7 (IC50 = 15.6nM @ 20min and 3.2nM @ 180 min). It displayed broad based antiproliferative activity with IC50’s of less than 200nM against 53% of the 1000 cancer cell lines it was tested against. THZ1 disrupts transcription of several proteins including RUNX1, TAL1, and GATA3. It suppresses oncogenic transcription of MYCN-driven cancers. THZ1 decreases STAT3 chromatin binding and expression of target genes such as MYC, PIM1, and others in peripheral T-Cell lymphoma cells with the Y640F STAT3 mutation. Addition of THZ1 to targeted cancer therapy increases cell death and hinders the development of drug-resistant cell populations in cellular and in vitro cancer models\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411077275988,"sku":"ABM148852-1","price":531.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411077308756,"sku":"ABM148852-2","price":131.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4120.png?v=1791105152","url":"https:\/\/www.abmium.com\/de\/products\/tribio-thz1-cdk7-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}