{"product_id":"tribio-su-9516-cdk-inhibitor-pan-specific","title":"SU-9516, CDK inhibitor (pan-specific)","description":"\u003cp\u003eA cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively. Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb\/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis. Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death. Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis. Cell permeable\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411074785620,"sku":"ABM148797-1","price":421.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411074818388,"sku":"ABM148797-2","price":123.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5705.png?v=1791105146","url":"https:\/\/www.abmium.com\/de\/products\/tribio-su-9516-cdk-inhibitor-pan-specific","provider":"ABMIUM","version":"1.0","type":"link"}