{"product_id":"tribio-sr-1001-rorag-agonist","title":"SR-1001, RORag agonist","description":"\u003cp\u003eA high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity. It inhibits the development of murine TH17 cells and suppresses the expression of cytokines. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model. Protects against pathologic neovascularization in various mouse models of retinopathy. Active in vivo\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411081634132,"sku":"ABM148767-1","price":523.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411081666900,"sku":"ABM148767-2","price":131.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1290.png?v=1791105163","url":"https:\/\/www.abmium.com\/de\/products\/tribio-sr-1001-rorag-agonist","provider":"ABMIUM","version":"1.0","type":"link"}