{"product_id":"tribio-sj6986-gspt1-molecular-glue","title":"SJ6986, GSPT1 molecular glue","description":"\u003cp\u003ePotent (IC 50 = 15 nM for Cereblon; EC 50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1\/2 (GSPT1\/2). It displayed selectivity for GPST1\/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411069641044,"sku":"ABM148743-1","price":327.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411069673812,"sku":"ABM148743-2","price":100.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3933.png?v=1791105004","url":"https:\/\/www.abmium.com\/de\/products\/tribio-sj6986-gspt1-molecular-glue","provider":"ABMIUM","version":"1.0","type":"link"}