{"product_id":"tribio-sc-560-selective-cox-1-inhibitor","title":"SC-560, Selective COX-1 inhibitor","description":"\u003cp\u003eSC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1). SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411060072788,"sku":"ABM148717-1","price":319.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411060105556,"sku":"ABM148717-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2531.png?v=1791104979","url":"https:\/\/www.abmium.com\/de\/products\/tribio-sc-560-selective-cox-1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}